Quantifying the Balance Between Total Bone Formation and Total Bone Resorption: An Index of Net Bone Formation
نویسندگان
چکیده
منابع مشابه
Monitoring of bone resorption and bone formation in multiple myeloma.
The article deals with the clinical value of monitoring of serum markers of osteoresorption (ICTP) and bone formation (PICP) in multiple myeloma. In a group of patients treated by conventional chemotherapy and group of patients treated by high dose chemotherapy with autologous peripheral blood stemm cell transplantation (APBSTC).
متن کاملGenistein prevents bone resorption diseases by inhibiting bone resorption and stimulating bone formation.
UNLABELLED Genistein, a soybean-derived isoflavone, has been shown to suppress osteoclastic bone resorption. To clarify the mechanisms underlying this action, we investigated the effects of genistein on the differentiation, cytoskeleton and function in mice osteoclasts in vitro and bone metabolism in ovariectomized rats. STUDY DESIGN Primary OCs were isolated from 3 week-old mice and induced ...
متن کاملBone Balance within a Cortical BMU: Local Controls of Bone Resorption and Formation
Maintaining bone volume during bone turnover by a BMU is known as bone balance. Balance is required to maintain structural integrity of the bone and is often dysregulated in disease. Consequently, understanding how a BMU controls bone balance is of considerable interest. This paper develops a methodology for identifying potential balance controls within a single cortical BMU. The theoretical fr...
متن کاملPPARG Post-translational Modifications Regulate Bone Formation and Bone Resorption
The peroxisome proliferator-activated receptor gamma (PPARγ) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. However, clinical use of TZDs has been limited by side effects including a higher risk of fractures and bone loss. Here we demonstrate that t...
متن کاملBone Formation Bone Resorption/Inflammation OsteoGenomicTM Profile Results
TNF-alpha (TNF-α): Tumor necrosis factor-alpha is a pro-inflammatory cytokine that can contribute to arthritis, asthma, and osteoporosis. Polymorphisms of TNF-α inappropriately activate inflammatory response and increase TNF-α production. Bone Resorption/Inflammation IL-6: Interleukin-6 is a cytokine that participates in the production of osteoclasts and potentiates bone resorption by other cyt...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2016
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2015-4262